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Pentobarbital, also known as pentobarbitone in British English and by the brand name Nembutal, is a short-acting psychoactive drug of the barbiturate class which produces powerful anxiolytic, hypnotic, muscle relaxant and amnesic effects. Pentobarbital can occur as both a free acid and as salts of elements such as sodium (Pentobarbital Sodium, Nembutal Sodium) and calcium. The free acid is only slightly soluble in water and ethanol.
Pentobarbital is used short-term to treat insomnia. Pentobarbital is also used as an emergency treatment for seizures, and to cause you to fall asleep for surgery.
In high doses, pentobarbital causes death by respiratory arrest. In the United States, the drug has been used for executions of convicted criminals.
Typical applications for pentobarbital are sedative, hypnotic for short term, preanesthetic and control of convulsions in emergencies.
It is also used as a veterinary anesthetic agent.
Pentobarbital also has an application in reducing intracranial pressure in Reye’s syndrome, traumatic brain injury and induction of coma in cerebral ischemia patients. Pentobarbital-induced coma has been advocated in patients with acute liver failure refractory to mannitol.
Pentobarbital can induce death when used in high doses. It is used for euthanasia for humans as well as animals. It is also used by itself, or in combination with complementary agents such as phenytoin, in commercial animal euthanasia injectable solutions.
In the Netherlands, the standard protocol for physician-assisted suicide is intravenously induced thiopental anesthesia, followed by bromide of alcuronium- or pancuronium-induced respiratory arrest. A concentrated oral solution of 100 mL containing 9 grams of pentobarbital sodium along with sugar syrup in a 20% ethanol solution is a standard solution used for self-administration by patient.
The oral dosage of pentobarbital indicated for physician-assisted death in the United States states of Oregon, Washington, Vermont, and California (as of January, 2016) is typically 10 g in liquid form.
Pentobarbital has been used or considered as a substitute for other drugs traditionally used for capital punishment in the United States when they are in short supply. Such use however is illegal under Danish law…